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目的:获得一种包封率较高、具有一定缓释能力的柚皮苷固体脂质纳米粒的处方和制备工艺。方法:采用熔融乳化超声法制备纳米粒。通过单因素考察和正交设计法优化处方和制备工艺;通过包封率、粒径、Zete电位以及物理稳定性等评价脂质纳米粒的特性。结果:以硬脂酸为材料制备的固体脂质纳米粒为圆整的类球形实体粒子,平均粒径为78.68nm,Zeta电位为-43.5mV,包封率为61.27%,体外24h的累积溶出率为85%。结论:柚皮苷纳米粒的处方和制备工艺可行。
OBJECTIVE: To obtain a formulation and preparation process of naringin solid lipid nanoparticles with high entrapment efficiency and sustained release capacity. Methods: The nanoparticles were prepared by melt-emulsification ultrasound. The formulation and preparation process were optimized by single factor test and orthogonal design. The properties of lipid nanoparticles were evaluated by entrapment efficiency, particle size, Zeote potential and physical stability. Results: The solid lipid nanoparticles prepared from stearic acid were spherical and spherical solid particles with an average particle size of 78.68nm, a zeta potential of -43.5mV and an entrapment efficiency of 61.27% The rate is 85%. Conclusion: The prescription and preparation of naringin nanoparticles are feasible.