论文部分内容阅读
基于老药洛哌丁胺的新型Menin-MLL相互作用界面小分子抑制剂的合成和活性研究
【机 构】
：
中国科学院上海药物研究所 上海201203
【出 处】
：
2016年长三角药物化学研讨会
【发表日期】
：
2016年11期
其他文献
Histone deacetylases (HDAC) enzyme plays a significant role in transcriptional regulation by modifying the core histones of the nucleosome,therefore it has emerged as an important therapeutic target f
Synthesis of liguzinediol acetyl amino acid ester prodrugs and their biological evaluation as promis
The liguzinediol was a potential drug for the treatment of heart failure with high effect and low safety risk.However,in vivo pharmacokinetic study showed elimination half-life (t1/2) was too short,ac
Liguzineiol has been recently discovered as a potential agent for treatment of heart failure with low safety risk.In this manuscript,we have undertaken a systematic exploration of the liguzinediol pol
Discovery of novel inhibitors disrupting HIF-1α/von Hippel-Lindau interaction through shape-based sc
Major research efforts have been devoted to the discovery and development of compounds that inhibit the protein-protein interaction between HIF-1α and the von Hippel-Lindau protein (pVHL),the substrat
会议
Molecular Imaging of Mesenchymal Epithelial Transition Receptor (c-Met)Expression Using a Novel 18F-
The mesenchymal epithelial transition factor (c-Met) is a member of the tyrosine kinase growth factor receptor family.Apart from controlling cell migration and growth in embryogenesis,c-Met can contro
Hsp90 is a molecular chaperone responsible for facilitating maturation of client proteins include oncogenic tyrosine kinase,transcription cofactors and cell-cycle proteins,and has long been recognized
Microglia,the resident phagocytes of the CNS,plays an important role in the active immune defense and the progression of neuroinflammation.It is reported that inhibition of microglial activation contr