TargetedTherapy相关论文
A typical bedside-to-bench investigation of leukemogenic driver MEF2D fusion reveals new targeted th
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ASCO-GU是泌尿生殖肿瘤诊疗领域的标志性会议。2022 ASCO-GU会议上公布了帕博丽珠单抗辅助治疗延长随访与阿昔替尼/阿维鲁单抗联合......
Circular RNAs (circRNAs) are noncoding RNAs that form covalently closed loop structures. CircRNAs are dysregulated in ca......
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by its highly aggressive behavior, earl......
Fast reaction and long duration-application of dabrafenib plus trametinib in treatment of metastatic
The prognosis of patients with advanced melanoma is poor.The five-year recurrence rate is approximately 70％,whereas the o......
Diverse and precision therapies open new horizons for patients with advanced pancreatic ductal adeno
Pancreatic ductal adenocarcinoma (PDAC) is a common cause of cancer-related death, and most patients are with advanced d......
Modern therapy of acute myeloid leukemia(AML)began in 1973 with the first report of the successful combination of daunor......
ERK pathway regulated the programmed death ligand-1 (PD-L1) expression which was linked to the response of programmed de......
因高发病率及高病死率，肺癌的治疗模式越来越受到重视。非小细胞肺癌（NSCLC）约占肺癌患者总数的4/5，其中在3%~7%的患者中发现了棘皮动......
目的:分析特瑞普利单抗联合阿昔替尼治疗晚期肾细胞癌的初步疗效与安全性。方法:回顾性收集北京大学肿瘤医院接受特瑞普利单抗联合......
本研究经过广泛查阅文献的方式方法，统计近年来抗肿瘤血管生成靶向药物干预的药物，并对药物的研究药物干预进展进行总结?现如今抗肿......
Intracellular delivery of functional molecules,such as DNA probes and plasmids,is an important method for investigating ......
Advances in locoregional therapy for hepatocellular carcinoma combined with immunotherapy and target
Locoregional therapies (LRTs) of hepatocellular carcinoma (HCC) represented by ablation and TACE has become the main mea......
The CXCL12 (SDF-1)/CXCR4 chemokine axis:Oncogenic properties, molecular targeting, and synthetic and
Chemokine 12 (CXCL12),also known as stromal cell derived factor-1 (SDF-1) and a member of the CXC chemokine subfamily,is......
Androgen receptor (AR),a hormonal transcription factor,plays important roles during prostate cancer progression and is a......
Personalized cancer therapy is a cutting-edge area including all aspects of individualized patient management driven by ......
Singlet Oxygen Manipulation by Aptamer Functionalized Upconversion Nanocarrier for Targeted Cancer T
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A variety of organic and inorganic materials have been utilized to generate nanoparticles for drug delivery applications......
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目的 Targeted tumor imaging and therapy have attracted great attention in nanomedicine development.Due to the molecular ......
Efficacy and safety for sorafenib in Chinese patients with metastasis renal cell cancer:a single-cen
Objective RCC is considered to be one of the most treatment-resistant cancers and is the tenth cancer-related cause of d......
目的 Pancreatic cancer is a high-grade malignant and fatal tumor with a 5-yearsurvival rate of less than 5％。...
Extended radical resection combined with resection of celiac axis and molecular targeted therapy for
Objective There still exist many disputes regarding the treatment of advanced gallbladder carcinoma nowadays....
A novel strategy based on chemical-armed singlet oxygen for rationally enhancing small molecular-tar
Objective Cancer is defined as the second leading cause of death and has become a huge global health burden.The discover......
Objective Gastric cancer(GC)is one of lethal diseases that ranks the second leading cause for cancer deaths and the fift......
hMex-3A Predicts Poor Prognosis and Contributes to The Tumor Progression of Hepatocellular Carcinoma
目的 To explore the exact role and molecular mechanism of hMex-3A in hepatocellular carcinoma(HCC)progression....
808 nm near infrared light excited UCNPs@mSiO2-Ce6-GPC3 nanocomposites for photodynamic therapy in l
Objective Liver cancer is an invasive tumor originating from the liver,it causes great harm to human health.Its global i......
Targeted of oncogenic hotspot mutant forms,p110αH1047R and p110αH1047L in p110α/ΔNp63α complex affec
Objective Hotspot constitutive activating of phosphatidylinositol 3 kinase(PI3K)signaling plays a critical role in metas......
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Clinicopathologic characteristics,immunohistochemical analysis,and outcome:a multicenter retrospecti
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Ki-67 labeling index may be a promising indicator to identify “very high risk” gastrointestinal stro
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Selective killing p53wT lung cancer cells harboring Arg72homozygote by a small molecular CypA inhibi
TP53, encoding a wellknown tumor suppressor p53, plays essential roles in tumor initiation and progression, and is frequ......
Efficacy and safety for sorafenib in Chinese patients with metastasis renal cell cancer:a single-cen
Purpose To evaluated the efficacy and safety of sorafenib for Chinese patients with mRCC.Methods We analyzed the clinica......
The preparation of polymeric prodrug of cisplatin based on pullulan and its therapeutic effects on h
Objective: To synthesize a polymeric prodrug of cisplatin (CDDP) based on pullulan and assess its effects on human hepat......
The PI3K/Akt/mTOR(PAM)signaling pathway plays a key regulatory function in cell survival,proliferation,migration,radioth......
Progress in the application and mechanism of metformin in treating non-small cell lung cancer (Revie
Currently,the incidence and mortality from lung cancer manifests an increasing trend.Non-small cell lung cancer (NSCLC) ......
H3K9 Demethylases Disable Oncogene-Induced Senescence and Serve As Therapeutic Targets For Senescenc
Cellular senescence is a stable cell-cycle arrest,which can be induced by over expressio no fonco genes,genetic mutatios......
Development of Small Molecules Targeting the Wnt Signaling Pathway in Cancer Stem Cells for the Trea
Colorectal cancer (CRC) was ranked third in morbidity and mortality in the United States in 2013.Although substantial pr......
Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confir
Mer is a receptor tyrosine kinase (RTK) with oncogenic properties that is often overexpressed or activated in various ma......
Targeted therapy and radiotherapyfor brain metastases in non-small lung cancer patients: When is the
The clinical outcomes of the sequential versus concurrenttherapy of targeted therapy andradiotherapy are still unconfirm......
Lipid Microbubbles Loaded Docetaxel(LDLM)Combined With Ultrasound-Targeted Microbubble Destruction I
aims Ultrasound microbubbles are now being used as carriers of drugs or genes in targeted treatment of carcinoma.The pur......
Circulating Tumor Cells and Evaluation of Targeted Therapy Effect in EGFR Mutation/ALK Translocation
Objective: Targeted therapies have considerably improved the prognosis of patients with non-small cell lung cancer (NSCL......
Objective Tenovin-6 is a newly reported small molecular inhibitor of Class Ⅲ HDACs or Sir2 family of enzymes.It has bee......
