PNPLA3相关论文
Interaction of SAMM50-rs738491, PARVB-rs5764455 and PNPLA3-rs738409 Increases Susceptibility to Nona
Background and Aims: Previous studies have reported that the single nucleotide polymorphisms (SNPs) of SAMM50-rs738491, ......
目的:系统评价Patatin类磷脂酶结构域3(PNPLA3)基因rs738409位点与酒精相关性肝病易感性的关系.方法:计算机检索中国知网、万方数......
目的:2型糖尿病（T2DM）由遗传因素和环境因素共同诱发,与非酒精性脂肪肝（NAFLD）密切相关。早期对T2DM以及其危险因素NAFLD做出预警并及......
目的:构建小鼠非酒精性脂肪性肝炎（nonalcoholic steatohepatitis,NASH）模型,确定NASH模型构建成功,检测肝脏和脂肪组织中miR-9表达......
非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)指在无过量饮酒史情况下,肝组织学改变类似于酒精性肝病,表现特征为细胞......
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, with increasing incidence worldwide. Alcohol......
Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 25％ of the worldwide population, and is the leading caus......
目的:国外已有一些研究报道关于PNPLA3 rs738409 SNP与HCC的相关性,但是目前国内尚缺乏PNPLA3 rs738409 SNP与HCC相关性的大样本病......
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
目的 研究中国汉族人群PNPLA3 rs738409 SNP与原发性肝癌发病的相关性.方法 217例原发性肝癌患者作为病例组,164名健康人作为对照......
PNPLA3基因在人类和哺乳动物体内都有表达,并且在肝癌细胞中也有表达.PNPLA3在人体和小鼠体内突变后可导致肝细胞内甘油三酯的蓄积......
利用基因剔除小鼠模型是研究未知功能基因的生物学功能的一种重要且有效的手段。在本研究中，我们利用两种基因剔除小鼠模型，分别研究......
非酒精性脂肪性肝病(NAFLD)正在成为我国一个新的公共健康问题[1].PNPLA3 (patatin-like phospholipase domain-containing protei......
目的 探讨PNPLA3基因rs738409 (C→G)多态性与青岛地区汉族人群慢性乙型肝炎的相关性.方法 收集185例慢性乙型肝炎(CHB)患者和164......
目的探讨PNPLA3基因I148M过表达的Huh7细胞中固醇调节元件结合蛋白(SREBP)-1c与甘油三酯的关系。方法用空病毒和携带PNPLA3基因I14......
目的探讨PNPLA3基因I148M多态性对人肝癌细胞株Huh-7细胞周期的影响及其相关机制。方法利用构建成功的稳定表达PNPLA3基因野生型和......
PNPLA3 as a Genetic Determinant of Risk for and Severity of Non-alcoholic Fatty Liver Disease Spectr
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Validation of genetic variants associated with metabolic dysfunctionassociated fatty liver disease i
BACKGROUND Genetic factors play an important role in the pathogenesis and development of metabolic dysfunction-associate......
PNPLA3蛋白属于patatin样磷脂酶家族,能够参与脂肪积累和脂肪动员,且该蛋白与肝脏炎症、肝纤维化密切相关。本研究旨在克隆PNPLA3......
酒精性肝病是由长期酗酒引起的肝功能损伤,对全球公众健康和社会发展造成严重威胁。但是,酒精性肝病的发病具有很大的个体差异。与......
Patatin-like phospholipase domain-containing 3(PNPLA3 or adiponutrin) displays anabolic and catabolic activities in lipi......
目的系统评价PNPLA3rs738409基因突变与非酒精性脂肪性肝病肝损伤的相关性。方法计算机检索PubMed、CNKI、Embase、Ovid数据库，搜索......
目的 评估PNPLA3I148M基因多态性与乙型肝炎肝硬化相关性.方法 本研究纳入乙肝肝硬化患者154例和健康对照组150例,对照组无乙型肝......
目的 探讨PNPLA3基因多态性与肝癌易感性关系.方法 计算机检索数据库,收集有关PNPLA3基因多态性与肝癌病易感性关系病例对照研究,......
One of the most common complications of childhood obesity is the non-alcoholic fatty liver disease(NAFLD),which is the m......
AIM To examine the association of PNPLA3 polymorphisms in chronic hepatitis C patients and development of liver disease ......
肝脏脂肪蓄积是非酒精性脂肪肝（nonalcoholic fatty liver disease,NAFLD）、酒精性肝病（alcoholic liver disease,ALD）的普遍现象,并与......
非酒精性脂肪肝(Nonalcoholic fatty liver disease,NAFLD)指在无过量饮酒史情况下,肝组织学改变类似于酒精性肝病,表现特征为细胞......
Linked PNPLA3 polymorphisms confer susceptibility tononalcoholic steatohepatitis and decreased viral
AIM To investigate the association of PNPLA3polymorphisms with concurrent chronic hepatitis B（CHB） and nonalcoholic fatty ......
De novo non-alcoholic fatty liver disease(NAFLD) is a common late complication for long-term survivors after liver trans......
This review intends to uncover how information from large-scale genetic profiling(whole genome sequencing,and whole exom......
Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy
AIM To investigate the influence of PNPLA3 genotype in heavy drinkers on serum markers and liver stiffness(LS) during al......
Non-alcoholic fatty liver disease (NAFLD)is now the most common cause of chronic liver diseases worldwide.It encompasses......
Understanding the pathophysiological mechanisms inthe pediatric non-alcoholic fatty liver disease： T
Classically, the non-alcoholic fatty liver disease （NAFLD）physiopathology and progression has been summarizedin the two hi......
PNPLA3基因在人类和哺乳动物体内都有表达,并且在肝癌细胞中也有表达。PNPLA3在人体和小鼠体内突变后可导致肝细胞内甘油三酯的蓄......
回 回 产卜爹仇贱回——回 日E回。”。回祖 一回“。回干 肉果幻中 N_。NH lP7-ewwe--一”＄ MN。W;- __._——————》 砧叫]们......
肝细胞癌(hepatocellular carcinoma,HCC)个体之间发病率及疾病进程的不同,提示遗传因素在HCC发生发展过程中至关重要。目前有研究......
肝细胞癌(hepatocellular carcinoma,HCC)位居全球恶性肿瘤发病率第六位,每年有748300新发病例;死亡原因占第三位,每年有695900死......
非酒精性脂肪肝代表一类肝细胞大量甘油三酯聚集而导致的肝脏疾病,按照严重程度可以分为脂肪变性、脂肪肝、肝脏纤维化和硬化。大......
背景:非酒精性脂肪性肝病(NAFLD)已成为全球第一大慢性肝病,是全球范围内重要的公共卫生问题之一,其可由单纯性脂肪肝进展为非酒精......
目的酒精性肝病(alcoholicliverdisease,ALD）作为一种遗传-行为-环境相互作用导致的疾病,其发病机制非常复杂,包括酒精性脂肪肝、酒......
目的分析中国成人非酒精性脂肪性肝病(NAFLD)患者PNPLA3基因多态性与肝脏损害的相关性,探讨遗传因素在中国成人NAFLD发生和发展中......
目的:探讨mi R196a-2基因rs11614913、rs12304647位点和PNPLA3基因rs738409、rs139047位点多态性与慢性HBV感染不同转归的关系。方......
PNPLA3（patatin-like phospholipase domain-containing 3）是由481个氨基酸组成的脂肪滋养蛋白（adiponutrin），属于patatin样磷脂酶域（PNP......
目的:目前医学认为,癌症的发生和发展是一个复杂的过程,是遗传因素和环境因素及其相互作用产生的结果。含pa t a t in样磷脂酶域3(......
目的慢性乙型肝炎（Chronic hepatitis B, CHB）已成为一种世界性慢性肝脏疾病。CHB与病毒基因型、年龄、环境因素、宿主因素等因素有......
