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Study on the induction of in vivo hippocampal long-term depression and its modulation by amyloid β-p
[会议论文] 作者：Li CHENG,Jin-Shun QI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Accumulation and deposition of amyloid-β peptide (Aβ P) in brain areas have been widely believed to play a critical role in the pathogenesis of Alzheimer s disease (AD).AβP may be responsible for much...
[Glyl4]-Humanin reverses depressive actions of amyloid β-protein fragment 25-35 on long-term potenti
[会议论文] 作者：Fen GUO,Wei JING,Jin-Shun QI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Alzheimers disease (AD) is the most prevalent neurodegenerative disease in aged people leading to progres-sive loss of memory and cognitive deficits.One of the major pathological features in AD brain...
Arginine vasopressin reversed Aβ25-35-induced depression of hippocampal long-term potentiation in ra
[会议论文] 作者：Wei JING,Fen GUO,Jin-Shun QI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
The main pathological characteristics of Alzheimers disease (AD) is the high density of senile plaques (SPs) in the brain which constitute of amyloid β-peptide (Aβ).However,the possible mechanisms by...
Protein kinase C mediates the amyloid β-protein fragment 31-35-Induced suppression of hippocampal la
[会议论文] 作者：Jun-Fang ZHANG,Jin-Shun QI,Jian-Tian QIAO,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Alzheimers disease (AD) is the most common cause of dementia in the elderly,characterized mostly by cognitive deficits and progressive loss of memory.Amyloid β (Aβ) protein is widely thought to play a...
[会议论文] 作者：Ming Hao,Jia-Qing Tong,Sheng-Xiao Zhang,Jin-Shun Qi,
来源：中国生理学会第24届全国会员代表大会暨生理学学术大会 年份：2014
Extensive research has shown that the aggregation and toxicity of amyloid -beta protein (A β) are closely related to the cognitive deficits in Alzheimers disease (AD).Inhibition of mammalian target of...
Val8-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β pe
[会议论文] 作者：Xiao-Hui Wang,Wei Yang,Zhao-Jun Wang,Hong-Yan Cai,Qing-Shan Li,Jin-Shun Qi,
来源：International Conference for Physiological Sciences 2012(201 年份：2012
Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimers disease (AD) in the elderly.Glucagonlike peptide-1 (GLP-1), a modulator used in T2DM therapy, has been shown to have neuroprotective pro...
[Gly14]-humanin abolished Aβ31-35-induced neurotoxicity by activating STAT3 transcription factor pat
[会议论文] 作者：Li YUAN,Xiao-Jie LIU,Zhao-Jun WANG,Wei-Na HAN,Wei YANG,Jin-Shun QI,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Objective Humanin (HN) is a 24-amino acid bioactive peptide abolishing neuronal cell death induced by various familial AD-related genes and amyloid-β (Aβ).[Gly14]-humanin (HNG), a derivative of HN, ha...
Neuroprotective effect of Val8-GLP-1(7-36) against a 1-40-induced neurotoxicity and its possible mec
[会议论文] 作者：Xiao-Hui WANG,Zhao-Jun WANG,Dong YANG,Li YUAN,Shao-Feng LI,Jin-Shun QI,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Objective One of the neuropathological features of Alzheimers disease (AD) is high density of senile plaques, mainly composed of amyloid β protein (Aβ).It has been found that type 2 diabetes mellitus...
[会议论文] 作者：Zhao-Jun WANG,Tomohiro Chibab,Wei-Na HAN,Xiao-Jie LIU,Li YUAN,Jin-Shun QI,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Objective Amyloid β protein (Aβ) has been thought to be responsible for loss of memory in Alzheimers disease (AD).Rattin (RN), a Humanin-like peptide with 38 amino acids (14 residues longer than Human...
[会议论文] 作者：Zhao-Jun Wang,Xiao-Hui Wang,Jia-Qing Tong,Li Yuan,Jun Zhang,Tian Li,Jin-Shun Qi,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Objective Rattin,a specific derivative of humanin in rats,can protect against amyloid β(Aβ)peptide-induced deficits in cognitive behavior and synaptic plasticity in rats,but the underlying mechanism i...
Brain-derived neurotrophic facter prevents against amyloid β protein-induced impairment of hippocamp
[会议论文] 作者：Qing-Shan Li,Wei Yang,Yan-Fang Pan,Jie Min,Zhe Zhang,Hui-Zhong Gao,Jin-Shun Qi,
来源：International Conference for Physiological Sciences 2012(201 年份：2012
Introduction: Brain-derived neurotrophic factor (BDNF) improved the spatial learning and memory impaired by accumulated β amyloid protein (Aβ) 25-35, to explore BDNF protection mechanism whether to ch...
Rattin protects against Aβ25-35 indued impairments in synaptic plasticity and spatial cognition of r
[会议论文] 作者：Zhao-jun Wang,Chibat Tomohiro,Wei-na Han,Xiao-jie Liu,Qing-shan Li,Li Yuan,Jin-shun Qi,
来源：International Conference for Physiological Sciences 2012(201 年份：2012
Rattin (RN), a humanin-like peptide, shared with Humanin ability to protect neurons against amyloid β protein (Aβ)-induced cellular toxicity.However, it is unclear whether RN can prevent Aβ-induced de...
[会议论文] 作者：张军,Lin-Lin Kong,Li Yuan,Jia-Qing Tong,Ming Hao,Sheng-Xiao Zhang,Jin-shun Qi,
来源：中国生理学会第24届全国会员代表大会暨生理学学术大会 年份：2014
Amyloid β protein(Aβ)is the main component of extracellular senile plaques in the brain of patients with Alzheimers disease(AD).It is reported that Aβ aggregation and Aβ-induced neurotoxicity could be...
[会议论文] 作者：Jun Zhang,Li Yuan,Yu-Fei Han,Ju Yang,Hui Shi,Sheng-Xiao Zhang,Jin-shun Qi,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Objective Long-term potentiation(LTP)of synaptic transmission is thought to be a direct reflection of synaptic information storage and synaptic plasticity,which is closely related to learning and memo...
[会议论文] 作者：Yu-Fei HAN,Zhao-Jun WANG,Jun ZHANG,Li YUAN,Tian LI,Juan-Juan JIAO,Jin-Shun QI,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Objective Alzheimers disease(AD)is a progressive and degenerative disorder accompanied by cognitive impairment,but effective strategies against AD are currently not available.Epidemiological studies h...
Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Mode
[期刊论文] 作者：Jun-Ting Yang,Zhao-Jun Wang,Hong-Yan Cai,Li Yuan,Meng-Ming Hu,Mei-Na Wn,Jin-Shun Qi,
来源：神经科学通报（英文版） 年份：2018
Alzheimer\'s disease (AD) is the most common form of dementia among the elderly,characterized by amyloid plaques,neurofibrillary tangles,and neuroinflammation in the brain,as well as impaired cognitive behaviors.A sex difference in the prev......
The Behavioral Study on the Neuroprotection of GLP-1/GIP/GCG Receptor Triagonist in Triple-transgeni
[会议论文] 作者：Juan-Juan JIAO,Tian-LI,Xue-Fan DONG,Xue-Song QU,Yue-CAO,Jun-ZHANG,Zhao-Jun WANG,Mei-Na WU,Jin-Shun QI,
来源：2016年国际生理学学术大会 年份：2016
Objective Alzheimers disease(AD)is a progressive neurodegenerative disorder which is still irreversible up to now.The typical symptoms of AD is memory loss,as well as other mental disorders.Recent evi...
GLP-1 analogue CJC-1131 Rescues Spatial Cognition and Synaptic Plasticity of Rats from Aβ1-42-induce
[会议论文] 作者：Sheng-Xiao Zhang,Hong-Yan Cai,Jun Zhang,Yu-Wei Zhang,Hui Zhao,Qiong Wang,Song-Jie Ren,Jin-Shun Qi,
来源：中国生理学会第24届全国会员代表大会暨生理学学术大会 年份：2014
Although the amyloid β protein (Aβ) aggregated in the brain has been recognized as one of the main pathological characteristics in Alzheimers disease (AD),the effective strategies against the Aβ neuro...
[会议论文] 作者：Ju Yang,Li Yuan,Hui Shi,Yu-Fei Han,Xue-Song Qu,Tian Li,Juan-Juan Jiao,Xue-Fan Dong,Jin-Shun Qi,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Objective Alzheimer disease(AD)is a fatal neurodegenerative disorder characterized by progressive cognitive impairment and memory loss....
[会议论文] 作者：Li YUAN,Jun ZHANG,Yu-Fei HAN,Hui SHI,Ju YANG,Sheng-Xiao ZHANG,Mei-Na WU,Zhao-Jun WANG,Jin-Shun QI,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Objective Alzheimers disease(AD)is the most common type of dementia,which seriously affects the life quality of the elderly,but no effective treatment is found up to now....
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