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[会议论文] 作者：Honglin Li,
来源：中国化学会第14 届全国计算(机)化学学术会议暨分子模拟国际论坛 年份：2017
Activator protein 1(AP-1)is a transcription factor that regulates a variety of protein-encoding genes,it is a participant in many cellular functions,includi...
[会议论文] 作者：Qiao Li,Honglin Li,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Peptides play a crucial in controlling and modulating protein-protein interactions and gain a wide research interest.However,rational design of therapeutic peptides with high affinity has been a major...
Statistical Analysis,Investigation,and Prediction of the Water Positions in the Binding Sites of Pro
[会议论文] 作者：Wei Xiao,Honglin Li,
来源：中国化学会第14 届全国计算(机)化学学术会议暨分子模拟国际论坛 年份：2017
Water molecules play a crucial role in biomolecular associations by mediating a hydrogen bond network or filling spaces with van der Waals interactions....
Palladium-Catalyzed Cyclization Reaction of o-Haloanilines, CO2 and Isocyanides: Access to Quinazoli
[期刊论文] 作者：Wen-Zhen Zhang,Honglin Li,Yang,
来源：黑龙江科技学院学报 年份：2018
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7...
Research on the Seismic-Geological Conditions for a Large Transformer Substation-A Case Study in the
[期刊论文] 作者：He Yulin,He Honglin,Li Yong,
来源：中国地震研究：英文版 年份：2007
地震地质的灾难能显然在三个方面影响一个设计地点：第一被扎根指责由地震引起了；第二是充分的理由运动；第三是象山崩，泥岩石流动和液化那样的地质的灾难。通过在四川省的 Shimian......
[期刊论文] 作者：Fangshu Wu,Junsheng Zhu,Honglin Li,Lili Zhu,,
来源：Acta Pharmaceutica Sinica B 年份：2017
UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α–triggered NF-κB activation. T...
[会议论文] 作者：Fang Bai,Xicheng Wang,Honglin Li,Hualiang Jiang,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Traditionally,drug discovery is driven by binding affinity under the argument that binders with higher binding affinity to a target should be more efficacious than those with lower binding affinity to...
[会议论文] 作者：Fang Bai,Jufeng Gu,Xicheng Wang,Honglin Li,Hualiang Jiang,
来源：第十一届全国计算(机)化学学术会议 年份：2011
...
Optical Cu2+ probe bearing an 8-hydroxyquinoline subunit: high sensitivity and large fluorescence en
[会议论文] 作者：Jiangli Fan,Hao Zhu,Jing Lu,Honglin Li,Xiaojun Peng,
来源：International Symposium on Electronic/Optic Functional Molec 年份：2012
...
Optical Cu2+ probe bearing an 8-hydroxyquinoline subunit: high sensitivity and large fluorescence en
[会议论文] 作者：Jiangli Fan,Hao Zhu,Jing Lu,Honglin Li,Xiaojun Peng,
来源：International Symposium on Electronic/Optic Functional Molec 年份：2012
A new fluorescent and colorimetric probe RCu1 with ultra-sensitivity (detection limit is 4.7 nM (3σ)) was developed.It is based on a rhodamine B derivative modified with a functionalized 8-hydroxyquin...
[会议论文] 作者：Fang Bai,Jufeng Gu,Xicheng Wang,Honglin Li,Hualiang Jiang,
来源：第十一届全国计算(机)化学学术会议 年份：2011
...
Numerical simulation of broken pin effects on the flow field and cooling performance of a double-wal
[期刊论文] 作者：Wenjing GAO,Honglin LI,Lei LI,Zhe’nan ZHAO,Zhufeng YUE,
来源：中国航空学报（英文版） 年份：2021
In this paper, the flow characteristics of the double wall structure are presented and the effect of the broken pin size on the cooling performance and flow fie...
[会议论文] 作者：Xiaofeng Liu,Fang Bai,Weiqiang Lu,Jin Huang,Honglin Li,Hualiang Jiang,
来源：2009长三角药物化学研讨会 年份：2009
...
[会议论文] 作者：Xiaofeng Liu,Fang Bai,Weiqiang Lu,Jin Huang,Hualiang Jiang,Honglin Li,
来源：2009长三角药物化学研讨会 年份：2009
...
Discovery,Optimization,X-ray Crystallographic Analysis and Biological Evaluation of Novel Thiazole D
[会议论文] 作者：Wenlin SONG,Yi TONG,Liuxin XU,Xuhong QIAN,Yufang XU,Honglin LI,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Human dihydroorotate dehydrogenase(hsDHODH),a flavin-dependent mitochondrial enzyme,plays a rate-limiting role in pyrimidine de novo biosynthesis,which has been identified as a potential target for th...
Discovery,Optimization,X-ray Crystallographic Analysis and Biological Evaluation of Novel Thiazole D
[会议论文] 作者：Wenlin SONG,Yi TONG,Liuxin XU,Xuhong QIAN,Yufang XU,Honglin LI,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Human dihydroorotate dehydrogenase(hsDHODH),a flavin-dependent mitochondrial enzyme,plays a rate-limiting role in pyrimidine de novo biosynthesis,which has been identified as a potential target for th...
[期刊论文] 作者：Wen Yang,Xia Wang,Kenan Li,Yuanru Liu,Ying Liu,Rui Wang,Honglin Li,
来源：定量生物学（英文版） 年份：2019
Background:Arachidonic acid (AA) metabolic network is activated in the most inflammatory related diseases,and small-molecular drugs targeting AA network are inc...
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekee
[会议论文] 作者：Yanli Jin,Ke Ding,Honglin Li,Mengzhu Xue,Xiaoke Shi,Chengyan Wang,Jingxuan Pan,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Background: Like T315I Bcr-Abl, T674I FIP1L1-PDGFRα existed in a subset of chronic eosinophilic leukemia (CEL) is also gatekeeper mutation that is resistant to tyrosine kinase inhibitors (TKIs, e.g.,...
[会议论文] 作者：Yongjia Hao,Deheng Sun,Yuqiong Xu,Zhenjiang Zhao,Zhuo Chen,Honglin Li,Yufang Xu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Most advanced non-small-cell lung cancer(NSCLC)with activating epidermal growth factor receptor(EGFR)mutations(exon 19 deletions or L858R)initially respond to the EGFR tyrosine kinase inhibitors(TKIs)...
[期刊论文] 作者：Na Luo,Xiaoyu Fang,Mingbo Su,Xinwen Zhang,Dan Li,Honglin Li,Shiliang Li,Zhenjiang Zhao,
来源：中国化学（英文版） 年份：2021
Dipeptidyl peptidase 4(DPP-4)is a clinically validated target for the treatment of type 2 diabetes mellitus(T2DM).To discover novel and potent DPP-4 inhibitors,...
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