论文部分内容阅读
眼的免疫赦免起因于眼自身对全身免疫反应诱导和表达的修饰。将抗原接种于眼前房可以诱导一种偏离形式的全身性免疫反应 ,称为前房相关免疫偏离 (ACAID)。ACAID的主要特征是 :( 1)抗原特异性迟发型超敏反应 (DTH)和补体结合性抗体反应的缺陷 ;( 2 )产生独特的调节性T细胞亚群。这种偏离式反应一方面保护了视力的完整性 ,免受诸如外伤、感染和炎症反应的持续性威胁 ;另一方面 ,也赋予了眼易发诸如肿瘤持续性生长和疱疹病毒感染后急性视网膜坏死的危险性。
Immune amnesia of the eye results from the modification of the eye itself to the induction and expression of the systemic immune response. Vaccination of the antigen in the anterior chamber can induce a deviated form of the systemic immune response called anterior chamber-associated immune bias (ACAID). The main features of ACAID are: (1) defects in antigen-specific delayed-type hypersensitivity (DTH) and complement-bound antibody responses; and (2) generation of unique regulatory T-cell subsets. On the one hand, such a deflected reaction protects the integrity of the eyesight against persistent threats such as trauma, infections and inflammatory reactions; on the other hand, it also imparts to the eye the development of acute retina such as persistent tumor growth and herpes virus infection The risk of necrosis.