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本实验采用冷暴露动物模型，研究沙棘油对动物实验性冷损伤的保护作用，冷暴露１周及２周后进行血液指标的分析，结果显示：①大鼠于０℃～２℃下冷暴露１周后，与对照组相比血中环－磷酸腺苷（ｃＡＭＰ）、环－磷酸鸟苷（ｃＧＭＰ）含量、丙二醛（ＭＤＡ）值、谷胱甘肽过氧化物酶（ＧＳＨＰｘ）和超氧化物歧化酶（ＳＯＤ）活性均明显增高；冷暴露２周后，血中ｃＡＭＰ、ｃＧＭＰ含量与ＭＤＡ值继续升高，而ＧＳＨＰｘ及ＳＯＤ活性却明显下降。②如饲料中添加一定量的沙棘油，冷暴露后大鼠上述指标均有改善，接近对照组水平，提示沙棘油对提高机体耐寒力是有益的，其机理与影响机体环核苷酸代谢及其抗脂质过氧化作用有关。
In this study, the animal model of cold exposure was used to study the protective effect of seabuckthorn oil on experimental cold injury in rats. After 1 week and 2 weeks of cold exposure, the blood parameters were analyzed. The results showed that: ① rats were exposed to cold at 0 ℃ ~ 2 ℃ After 1 week, the levels of cAMP, cGMP, MDA, GSH-Px, And superoxide dismutase (SOD) activity were significantly increased; cold exposure after 2 weeks, the blood cAMP, cGMP content and MDA values continued to increase, and GSH Px and SOD activity was significantly decreased. (2) If a certain amount of seabuckthorn oil was added into the feed, the above indexes of rats after cold exposure were all improved, which were close to those of the control group, suggesting that seabuckthorn oil is beneficial to improve the cold tolerance of the body, and its mechanism is related to the cyclic nucleotide metabolism Its anti-lipid peroxidation related.