本发明公开了一种制备1,4-戊二炔-3-醇的方法,属有机合成领域。包括如下步骤:首先将镁条与溴乙烷溶液反应制得乙基溴化镁溶液;而后通入乙炔气体与乙基溴化镁溶液反应得到乙炔基溴化镁;将乙炔基溴化镁与甲酸乙酯反应得中间体I;最后将中间体I水解、萃取、干燥、精制后得到白色晶体状1,4-戊二炔-3-醇产品。 The invention discloses a method for preparing 1,4-pentadiyn-3-ol, which belongs to the field of organic synthesis. The method comprises the following steps: firstly, an ethyl magnesium bromide solution is prepared by reacting a magnesium bar with an ethyl bromide solution; then an acetylene magnesium bromide is obtained through reaction of an acetylene gas and an ethyl magnesium bromide solution; Ethyl formate intermediate I; finally the intermediate I hydrolyzed, extracted, dried and purified to give the white crystalline 1,4-pentadiyn-3-ol product.