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目的:探讨补中益气丸治疗原发性肾病综合征的疗效和安全性。方法:将72例患者按入院顺序随机分为两组,补中益气丸36例给予泼尼松片、辛伐他汀片、复方丹参片基础上加服补中益气丸素治疗。环孢霉素组35例给予上述治疗方法上加服环孢霉素。16周后评定两组疗效和安全性。结果:补中益气丸组总有效率91.4%;环孢霉素组组总有效率91%;两组疗效相仿,但补中益气丸对症状及体征的改善稍差于环孢霉素组,补中益气丸组的安全性高于环孢霉素组。结论:补中益气丸治疗肾病综合征疗效确切,副反应较小。
Objective: To investigate the efficacy and safety of Buzhongyiqi pill in the treatment of primary nephrotic syndrome. Methods: Seventy-two patients were randomly divided into two groups according to the order of admission. 36 cases of Buzhongyiqi pill were given prednisone tablets, simvastatin tablets and Fufang Danshen tablets. Cyclosporine group 35 patients given the above treatment plus cyclosporine. After 16 weeks, the curative effect and safety of both groups were evaluated. Results: The total effective rate of Buzhongyiqi pill group was 91.4%; the total effective rate of cyclosporin group was 91%; the two groups had similar curative effect, but Buzhongyiqi pill had less improvement on symptoms and signs than that of cyclosporine Group, Buzhongyiqi pill group safety than cyclosporine group. Conclusion: Bu Zhong Yi Qi Wan is effective in treating nephrotic syndrome with less side effects.