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目的：观察大鼠糖尿病早期对头孢噻肟（ＣＴＸ）药代动力学的影响。方法：用四氧嘧啶制做大鼠糖尿病模型，高压液相（ＨＰＬＣ）方法测定ＣＴＸ的血药浓度，计算机计算各项药代参数。结果：糖尿病组动物的血药峰浓度和ＡＵＣ值明显低于对照组，但两组的吸收和消除半衰期没有明显差别。结论：提示在糖尿病早期不影响ＣＴＸ的吸收，而消除半衰期没有改变可能与在糖尿病状态下大鼠肝药酶活性降低和肾小球滤过率增加有关。
Objective: To observe the effect of early stage of diabetes on the pharmacokinetics of cefotaxime (CTX) in rats. Methods: Alloxan was used to make rat model of diabetes. The plasma concentration of CTX was determined by high pressure liquid chromatography (HPLC). The pharmacokinetic parameters were calculated by computer. Results: The plasma peak concentration and AUC of diabetic animals were significantly lower than that of the control group, but there was no significant difference between the two groups in the half-life of absorption and elimination. CONCLUSION: It is suggested that CTX absorption is not affected in the early stage of diabetes, and that the elimination half-life is unchanged may be related to the reduction of hepatic enzymatic activity and the increase of glomerular filtration rate in diabetic rats.