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目的 :探讨雌、孕激素受体 ( ER、PR)在前列腺癌组织中的表达 ,及其在临床治疗中的意义。方法 :对 3 0例未经抗癌治疗的前列腺癌石蜡包埋材料进行 ER、PR检测。结果 :ER阳性 9例 ( 3 0 .0 % )、PR阳性 8例 ( 2 6 .7% ) ,有 3例 ER、PR均阳性 ;分析表明ER、PR表达与癌组织分化程度无明确相关性 ;因随访仅 7例 ,未发现 ER、PR表达与生存期是否相关。结论 :前列腺癌中存在 ER、PR阳性表达 ,此结果可供临床选择治疗方案参考 ,并在一定程度上解释了女性激素可控制前列腺癌进展的机理
Objective: To investigate the expression of estrogen and progesterone receptor (ER, PR) in prostate cancer and its clinical significance. Methods: ER and PR were detected in 30 cases of prostate cancer paraffin embedded material without anticancer treatment. Results: There were 9 cases (30.0%) positive for ER, 8 cases (PR) positive for 8 cases (26.7%), and 3 cases were positive for ER and PR. There was no clear correlation between the expression of ER and PR and the differentiation of cancer ; Only 7 cases were followed up, no ER, PR expression and survival were related. Conclusion: There is positive expression of ER and PR in prostate cancer. The result is a reference for clinical choice of treatment regimen, and to a certain extent, explains the mechanism by which female hormones can control the progress of prostate cancer