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目的探讨特发性肺间质纤维化(IPF)患者疾病过程中血清MDA、PCⅢ、LN变化的临床意义以及其与IPF疾病严重程度(CRP评分)的关系。方法将106例IPF患者进行CRP评分,根据评分结果将患者分为高分组、中分组及低分组,采用硫巴比妥酸反应底物法(TBARs)测定IPF患者MDA含量,采用放射免疫分析法检测血清PCⅢ、LN含量;选择35例体检的健康人作为对照。结果 IPF患者患者血清MDA、PCⅢ、LN显著高于对照组(P<0.01),且随着病情加重上述指标有升高趋势。结论检测血清血清MDA、PCⅢ、LN对IPF患者肺纤维化的动态观察和早期诊断具有重要意义。
Objective To investigate the clinical significance of the changes of serum MDA, PC Ⅲ and LN in patients with idiopathic pulmonary fibrosis (IPF) and their relationship with the severity of IPF (CRP score). Methods One hundred and six patients with IPF were evaluated for CRP. The patients were divided into high, middle and low scores according to the scores. MDA content in patients with IPF was determined by thiobarbituric acid reactive substrate (TBARs) method. The radioimmunoassay Serum PCⅢ, LN levels were measured; 35 healthy subjects were selected as controls. Results The serum levels of MDA, PCⅢ, LN in patients with IPF were significantly higher than those in the control group (P <0.01). The above indexes increased with the progression of the disease. Conclusion Detecting serum serum MDA, PCⅢ, LN has important significance in the dynamic observation and early diagnosis of pulmonary fibrosis in patients with IPF.