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目的研究遗传优生咨询患者中染色体异常核型的发生率,探讨遗传因素在不良孕产史中的重要性,探讨染色体多态性对不良孕产史的影响,并做好优生指导。方法对患者外周血进行培养,细胞收获,制片及G显带,必要时进行C显带检查,显微镜下进行核型分析。结果 1543对不良孕产史的夫妇染色体核型分析,发现异常核型314例,阳性率为10.2%。染色体多态性239例,占异常总数的76.1%,染色体结构异常67例,占异常总数的21.3%,数目异常8例,占异常总数的2.5%。结论染色体异常与不良孕产史有着一定的相关性,因此对于不孕不育、不良孕产史的夫妇,染色体检查分析必须作为常规的检查方法,对于临床医生在遗传咨询过程中则应充分注意到染色体多态性与不良孕产史的相关性。
Objective To study the incidence of chromosomal abnormal karyotype in patients with genetic eugenics and to explore the importance of genetic factors in the history of adverse pregnancy and to explore the influence of chromosome polymorphism on the history of adverse pregnancy and to guide the development of eugenics. Methods The peripheral blood of patients were cultured, harvested, cultured and G - banding. C - banding was performed if necessary and karyotype analysis was performed under the microscope. Results 1543 pairs of maternal history of poor maternal karyotype analysis found that 314 cases of abnormal karyotype, the positive rate was 10.2%. Chromosome polymorphism 239 cases, accounting for 76.1% of the total number of anomalies, chromosomal abnormalities in 67 cases, accounting for 21.3% of the total number of anomalies, the number of abnormalities in 8 cases, accounting for 2.5% of the total number of anomalies. Conclusion Chromosome abnormalities and poor history of pregnancy have a certain correlation, so for infertility, poor couples history of pregnancy, chromosome analysis must be used as a routine examination method, for clinicians in the genetic counseling process should pay full attention Correlation between chromosomal polymorphism and poor pregnancy history.