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【目的】探讨白芍总苷联合沙利度胺治疗口腔扁平苔藓（OLP）的疗效。【方法】收集OLP患者124例，随机分为两组，每组各62例。观察组采用白芍总苷每次0．6 g ，3次／日，沙利度胺前10 d给予100 mg ，d11～d2075 mg ，d21～d5650 mg ，均1次／日，睡前顿服；对照组单用白芍总苷，用法同观察组，两组疗程均为8周。比较两组VAS疼痛评分有效率和临床有效率及不良反应。【结果】观察组 VAS疼痛评分有效率和临床有效率分别为83．87％、90．32％，显著高于对照组67．74％、74．19％，差异均有统计学意义（ P ＜0．05）。所有患者均未出现严重不良反应。【结论】白芍总苷联合沙利度胺治疗OLP疗效满意，且无明显不良反应，值得临床推广应用。“,”[Objective]To explore the therapeutic efficacies and adverse reactions of total glucosides of paeony cap‐sules (TGP) with thalidomide (TLD) in treatment of oral lichen planus .[Methods]A randomized controlled clinical trial was conducted .A total of 124 patients were randomized into treatment ( n =62) and control ( n = 62) groups .The treatment group received TGP 0 .6 g thrice daily and thalidomide 100 mg once daily for Day 1~10 ,75 mg once daily for Day 11~20 ,50 mg once daily for Day 21~56 ,dosing before bedtime (group A ) .And control group had TGP 0 .6 g thrice daily (group B) .Blood ,urine and stool routines ,liver and kidney functions were detected before and after 8‐week treatment .Also adverse reactions were monitored .[Results] The effective rate of subjective indicators was 83 .87% for group A and 67 .74% for group B .There was significant inter‐group difference ( P<0 .05) .The effective rate of objec‐tive indicators was 90 .32% for group A and 74 .19% for group B .There was significant inter‐group difference ( P <0 .05) .There was no onset of serious adverse events .[Conclusion]Compared with TGP alone ,TGP plus thalidomide is more efficacious for oral lichen planus with fewer side effects .