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目的 :观察血管紧张素Ⅱ受体拮抗剂氯沙坦对 5 / 6肾切除大鼠残余肾组织肾小球硬化的影响。方法 :将5 / 6肾切除鼠分为氯沙坦治疗组和对照组 ,并设假手术组为正常对照组。检测各组术后第 2 ,4,6周的尿蛋白及第 6周的血清尿素氮、肌酐、总蛋白、白蛋白 ,并观察第 6周肾组织病理改变。结果 :氯沙坦治疗组与对照组相比 ,尿蛋白排泄量明显减少 (P <0 .0 1) ,血肌酐、尿素氮水平下降 (P <0 .0 1) ,肾小球增生、硬化程度明显减轻。结论 :氯沙坦可减轻5 / 6肾切除鼠的肾功能损害 ,延缓残余组织肾小球硬化的进展。
Objective: To observe the effect of losartan, an angiotensin Ⅱ receptor antagonist, on renal residual glomerulosclerosis in 5/6 nephrectomized rats. Methods: 5/6 nephrectomized rats were divided into losartan treatment group and control group, and sham operation group was set as normal control group. Urine protein, serum urea nitrogen, creatinine, total protein and albumin were detected at 2, 4 and 6 weeks after operation in each group and pathological changes at 6th week were observed. Results: Compared with the control group, the urinary protein excretion was significantly decreased (P <0.01), serum creatinine, urea nitrogen level decreased (P <0.01), glomerular proliferation and sclerosis Significantly reduce the degree. CONCLUSION: Losartan can reduce renal damage in 5/6 nephrectomized mice and delay the progression of residual tissue glomerulosclerosis.