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Synthesis and characterization of the ligand, 10-(-hexadecylcarboxymethyl)-1,4,7,10-tetraazacyclododecane- 1,4,7-triacetic acid (H4L), and its Gd(III) chelate are described. Protonation constants for H4L (HlgiK=10.52, 9.45, 4.74, 4.10) and the stability constant for GdL- (-GdLlg K=24.50) were determined by potentiometric titrations. The results obtained show that the ligand still maintains the strong chelating properties of the parent DOTA (1,4,7,10-tetraazacyclododecane-N,N’,N’’N’’’-tetraacetic acid) after introduction of a linear chain hexadecyl group at the acetic side chain of DOTA, and its basicity is not significantly altered.
Synthesis and characterization of the ligand, 10 - (- hexadecylcarboxymethyl) -1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (H4L), and its Gd (III) chelate are described. Protonation constants for H4L (HlgiK = 10.52, 9.45, 4.74, 4.10) and the stability constant for GdL- (-GdLlg K = 24.50) were determined by potentiometric titrations. The results obtained show that the ligand still maintains the strong chelating properties of the parent DOTA , 4,7,10-tetraazacyclododecane-N, N ’, N’’N’ ’’ - tetraacetic acid) after introduction of a linear chain hexadecyl group at the acetic side chain of DOTA, and its basicity is not significantly altered.