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本文报告两例慢性白血病并发组织细胞型恶性淋巴瘤。一为慢淋,另一为慢粒,前者亦称Richter′s综合征。慢性白血病与恶性淋巴瘤合并存在,对其治疗及予后均有特殊意义,所以,对此及时明确诊断至关重要。然而,其临床表现,除常常有腹痛外,多不具特异性。只能根据组织学检查确定,尤以电镜检查更为确切。本组两例,瘤细胞胞浆丰富,胞浆膜可见局灶性的微密条纹,并见多数初级及次级溶酶体,膜下可见清晰的微饮泡。
This article reports two cases of chronic leukemia with histiocytic malignant lymphoma. One for the slow drench, the other for slow-grain, the former also known as Richter’s syndrome. Chronic leukemia and malignant lymphoma with the existence of its treatment and post-treatment are of special significance, therefore, timely diagnosis is crucial. However, its clinical manifestations, in addition to often have abdominal pain, the more non-specific. Only based on histological examination to determine, especially in electron microscopy more accurate. The two cases of this group, rich in cytoplasm of tumor cells, focal cytoplasmic micro-dense stripe can be seen, and see most of the primary and secondary lysosomes, the membrane can be seen clearly micro-drink bubble.