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蒽醌类衍生物为大黄中重要的活性成分。它们的化学结构不同或存在状态不同(游离或结合型)其药理药效差异较大。结合型大黄酸是正品大黄的主要标志之一。本文建立了结合型大黄酸的HPLC分离测定方法,为中成药的质量评价提供了方便和依据。
Anthraquinone derivatives are important active ingredients in rhubarb. Their chemical structures are different or exist in different states (free or combined) and their pharmacological effects are quite different. Combined rhein is one of the main signs of authentic rhubarb. In this paper, a method for the determination of combined rhein by HPLC was established, which provided convenience and basis for the quality evaluation of Chinese patent medicine.