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本文观察了丹参、蒲黄、大黄制剂对胃饲草鱼胆汁大鼠早期肾脏损害的影响。与模型组比较,上述药物能降低血肌酐和尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG酶),使肌酐清除率增加,减少近曲小管上皮细胞坏死及囊腔内有红细胞的肾小球数目。为中药治疗鱼胆中毒所致的肾脏损害提供初步依据。
This article observed the effects of Salvia miltiorrhiza, Puhuang and Rhubarb preparations on early kidney damage in stomach fed grass carp bile rats. Compared with the model group, these drugs can reduce serum creatinine and urinary N-acetyl-β-D-glucosaminidase (NAG enzyme), increase creatinine clearance, and reduce necrosis of proximal tubular epithelial cells and red blood cells in the cyst. The number of glomeruli. It provides preliminary basis for kidney damage caused by fish gall bladder poisoning.