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目的:探讨糖耐量减低患者血浆内皮素、一氧化氮、C反应蛋白水平变化。方法:葡萄糖耐量试验筛查出糖耐量减低患者90例和糖耐量正常的体检健康者18例,测定2组血浆内皮素、一氧化氮、C反应蛋白水平及胰岛素抵抗指数和胰岛素敏感指数。结果:糖耐量减低组血浆内皮素、C反应蛋白升高,一氧化氮下降,胰岛素抵抗指数升高,胰岛素敏感指数下降,与糖耐量正常组比较,差异有统计学意义(P<0.01)。结论:在糖耐量减低阶段已存在血管内皮功能紊乱,轻度炎症病变和胰岛素抵抗。
Objective: To investigate the changes of plasma endothelin, nitric oxide and C-reactive protein in patients with impaired glucose tolerance. Methods: Ninety patients with impaired glucose tolerance and 18 healthy subjects with normal glucose tolerance were screened by glucose tolerance test. Plasma endothelin, nitric oxide, C-reactive protein, insulin resistance index and insulin sensitivity index were measured in two groups. Results: The levels of plasma endothelin, C - reactive protein, nitric oxide, insulin resistance index and insulin sensitivity index decreased in patients with impaired glucose tolerance, the difference was statistically significant (P <0.01). Conclusion: There are vascular endothelial dysfunction, mild inflammation and insulin resistance in the stage of impaired glucose tolerance.