TMP(三甲氧苄胺嘧啶)的广谱抗菌作用,以及对许多种抗菌药物的增效作用,临床已甚熟悉。我科去年夏季用增效磺胺甲氧吡嗪(TMP——SMPZ)治疗急性菌痢的临床观察已有总结,肯定了这一药物的疗效(见本刊本期)。但是新磺胺在药源上目前仍感不足。而老的磺胺药源则甚丰富,使用也很广泛,若能改善其抗菌效能,就更有利于临床推广使用。所以我 The broad-spectrum antimicrobial effect of TMP (trimethoprim), as well as the synergistic effect of many antimicrobial agents, is already well known in the clinic. The clinical observations of our department on the treatment of acute bacillary dysentery with synergistic sulfamerazine (TMP - SMPZ) last summer have been summarized and confirmed the efficacy of this drug (see issue). However, the new sulfa drug source is still inadequate. The old sulfa drug source is very rich, the use is also very wide, if it can improve its antimicrobial efficacy, it is more conducive to the clinical promotion and use. So I