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为了解苯巴比妥联合止血敏预防早产儿颅内出血(ICH)效果,以92例胎龄<35周的早产儿为观察对象进行对照研究。预防组32例,对照组1与对照组2各30例,预防组入院后即给予苯巴比妥负荷量,以后给予维持量共5天,止血敏12.5mg/kg,每6小时1次,共4天;对照组1单用苯巴比妥,对照组2单用止血敏。结果显示预防组ICH的发生率(18.75％)较对照组1(43.33％)及对照组2(46.67%)显著降低(P<0.05),预防组与对照组1严重ICH的发生率(3.13％及3.33%)均较对照组2(26.67％)显著降低(P<0.05);预防组Ⅰ～Ⅱ级ICH的发生率(15.63％)较对照组1(4O％)显著降低(P<0.05)。由此可见苯巴比妥联合止血敏可显著降低早产儿ICH的发生率及严重度,并可降低Ⅰ～Ⅱ级ICH的发生率。
To investigate the effect of phenobarbital combined with hemostatic in preventing preterm infants with intracerebral hemorrhage (ICH), 92 pregnant women with gestational age <35 weeks were enrolled in this study. Prevention group of 32 cases, control group 1 and control group 2 each 30 cases, prophylaxis group was given phenobarbital load after admission, after the maintenance dose for a total of 5 days, hemostatic sensitivity 12.5mg / kg every 6 hours, A total of 4 days; control group 1 with phenobarbital alone, the control group 2 single with hemostatic sensitivity. The results showed that the incidence of ICH in prevention group (18.75%) was significantly lower than that in control group 1 (43.33%) and control group 2 (46.67%) (P <0.05) And 3.33% respectively) were significantly lower than those in control group 2 (26.67%) (P <0.05). The incidence of grade Ⅰ ~ Ⅱ ICH in prevention group was significantly lower than that in control group (40% vs. 15% . This shows phenobarbital combined hemostatic sensitivity can significantly reduce the incidence and severity of ICH in preterm children, and can reduce the Ⅰ ~ Ⅱ grade ICH incidence.