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NGR为肿瘤血管特异导向肽,将其与功能肽KV7连接构建成一导向功能多肽NGR-KV7;为研究该多肽与人肿瘤乳癌细胞的相互作用,应用核磁共振技术来探讨该多肽与细胞的作用位点和亲和性;通过1H NMR和T2弛豫谱的分析,推断该多肽分子与人乳癌细胞结合紧密,亲和程度高.
NGR is a tumor-specific targeting peptide, which is linked with the functional peptide KV7 to construct a functional-oriented polypeptide NGR-KV7. In order to study the interaction between the polypeptide and human tumorous breast cancer cells, NGR is used to investigate the interaction between the polypeptide and the cell Point and affinity. By 1H NMR and T2 relaxation spectrum analysis, it is inferred that the polypeptide molecule is closely associated with human breast cancer cells and has high affinity.