芫花酯甲和酯乙是有效的中期引产药。近期上海国际妇幼保健院用芫花酯甲抗早孕,亦获得良好效果。它们的作用机理被认为是药物导致蜕膜细胞变性、坏死,而使其中的溶酶体受到破坏,释放大量内源性前列腺素而引起的。本文观察药物对早孕及未孕大鼠离体子宫的收缩作用,为进一步了解其作用机理提供依据。 Yuanhua ester A and ester B is a effective mid-term induction drug. Recently, the Shanghai International Maternal and Child Health Hospital with yuanhuacai anti-pregnancy, also received good results. Their mechanism of action is thought to be caused by drugs that cause decidual cell degeneration and necrosis, which causes the lysosomes to be destroyed and release a large amount of endogenous prostaglandins. In this paper, we observed the contractile effect of drugs on isolated uterus in early pregnancy and nonpregnant rats to provide evidence for further understanding of its mechanism of action.