黑棘皮病是一种皮肤疾病。其并发肿瘤更为有害。为提高对本病的认识,本文将其行关问题综述如下。历史回顾:早在1867年、1890年Mitchell,Pollitzer及Janvosky就分别描述了本病,后由Unna命名为黑棘皮病(Canthosis Nigricans)。Pollitzer及Oarier还提到本病可并发胃肠道恶性肿瘤。1909年Pollitzer氏首先提出黑棘皮病还可能并发内分泌疾病。60年代以来,人们又逐渐认识到黑棘皮病患者多有细胞水平的抗胰岛素性,同时 Acanthosis nigricans is a skin disease. Its concurrent tumor is more harmful. In order to improve the understanding of this disease, this article summarizes the problems of the disease as follows. Historical Review: As early as 1867, Mitchell, Pollitzer and Janvosky described the disease separately in 1890, and later Unna named Canthosis Nigricans. Pollitzer and Oarier also mentioned the disease can be complicated by gastrointestinal cancer. 1901 Pollitzer’s first proposed acanthosis nigricans may also be complicated by endocrine disease. Since the 1960s, people have come to realize that patients with acanthosis nigricans have more cells at the level of insulin resistance, at the same time