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目的 探讨深圳市一般人群中庚型肝炎病毒 (HGV)感染情况及其影响因素。方法 采用随机抽样法选取研究对象 ,并用酶联免疫反应法 (ELISA)检测该人群中抗 -HGV抗体 ,对其中抗体阳性者用逆转录PCR(RT -PCR)检测血清中HGVRNA。结果 一般人群中抗 -HGV阳性率为 9 33% ,HGVRNA阳性率为 2 33% ,男女HGVRNA阳性率分别为 2 4 5 %和 2 2 0 % ,年龄组间HGVRNA阳性率差异无显著性 ;单因素和logistic回归分析未显示肝炎病史、近期手术史、注射史、拔牙史及乙型肝炎疫苗接种史等因素与HGV感染有关 ,HBsAg、抗 -HBs和抗 -HBc与HGV感染无统计学意义。不同职业人员中以中学生及教师的HGVRNA阳性率较高。结论 深圳市一般人群中HGV感染率较高 ,但其流行因素尚待进一步研究
Objective To investigate the prevalence of hepatitis G virus (HGV) in the general population in Shenzhen and its influencing factors. Methods The subjects were selected by random sampling method and the anti-HGV antibodies were detected by enzyme-linked immunosorbent assay (ELISA). The serum HGVRNAs were detected by reverse transcription polymerase chain reaction (RT-PCR). Results The prevalence of anti-HGV in the general population was 93.3%, the positive rate of HGVRNA was 23.3%, the positive rates of HGVRNA in male and female were respectively 24.5% and 220.0%, and there was no significant difference in the positive rate of HGVRNA between the groups Factors such as hepatitis history, history of recent surgery, history of injection, history of tooth extraction and history of hepatitis B vaccination were not shown by logistic regression analysis and other factors. There was no significant difference between HGV infection and HBsAg, anti-HBs, anti-HBc and HGV infection. HGVRNA positive rates among middle school students and teachers in different occupations were higher. Conclusion The prevalence of HGV in the general population in Shenzhen is high, but the prevalence of HGV remains to be further studied