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目的探讨慢性末端回肠炎(CTI)患者的小肠细菌过度生长(SIBO)情况,以及SIBO与其末端回肠炎症程度之间的关系。方法将98例CTI患者按末端回肠炎程度,分为轻度、中度、重度等3组,通过葡萄糖氢呼气试验(GHBT)分别检测其SIBO情况,并与健康对照组进行组间比较分析。结果 3组CTI患者与健康对照组的SIBO阳性率及试餐后呼气氢浓度比较均有显著差异(P<0.01)。CTI患者的SIBO阳性率及试餐后呼气氢浓度随着末端回肠炎症程度呈渐进性增高。各组间差异有显著性(P<0.05)。结论 CTI患者常存在SIBO,且随着末端回肠炎症程度的加重,其SIBO情况也加重。CTI患者的末端回肠炎症程度与其发生的SIBO之间有直接或间接的关联。
Objective To investigate the intestinal bacterial overgrowth (SIBO) in patients with chronic terminal ileitis (CTI) and the relationship between SIBO and the severity of terminal ileum inflammation. Methods 98 cases of CTI patients were divided into 3 groups according to their degree of terminal ileitis. SIBO was detected by GHBT, and compared with healthy control group . Results The SIBO positive rate and the post-prandial expiratory hydrogen concentration in three CTI patients and healthy control group were significantly different (P <0.01). The positive rate of SIBO in CTI patients and the expired hydrogen concentration after the meal showed gradual increase with the degree of terminal ileum inflammation. The differences among groups were significant (P <0.05). Conclusions SIBO often exists in patients with CTI, and its SIBO status aggravates as the degree of terminal ileum inflammation aggravates. There is a direct or indirect relationship between the degree of terminal ileal inflammation in CTI patients and the SIBO they occur.