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用于治疗类风湿性关节炎的关节内注射液,由于药物在关节内迅速被清除,进入循环后可导致全身作用。例如皮质类固醇在关节内给药后可引起血浆皮质醇抑制和血嗜酸细胞减少。为了研究生物降解性聚合物作为最大限度地保留药物和维持药物作用持续时间的关节内给药系统的可行性,作者制备了4种聚合物的胶体混悬液:聚乳酸(PLA)、聚丁基氰基丙烯酸酯(PBCA)、明胶(PG)和白蛋白(PA),粒子大小范围为1～10μm。并且用兔膝关节滑膜组织为材料,作了活体内的生物相容性试验,以评价关节内注射聚合
Intra-articular injection for the treatment of rheumatoid arthritis, due to the rapid elimination of drugs in the joints, into the circulation can lead to systemic effects. For example, corticosteroids can cause plasma cortisol inhibition and blood eosinophilia after intra-articular administration. In order to study the feasibility of biodegradable polymers as an intra-articular delivery system that preserves the drug and maintains the duration of the drug action, the authors prepared colloidal suspensions of four polymers: polylactic acid (PLA), poly (PBCA), gelatin (PG) and albumin (PA), with particle sizes ranging from 1 to 10 μm. And rabbit knee synovial tissue as a material, made in vivo biocompatibility test to evaluate intra-articular injection polymerization