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目的 :动态监测SARS病人IL 1α、IL 1β、TNFα和IL 6含量并探讨其意义。方法 :采用酶联免疫吸附法定量检测早期、恢复期SARS病人以及出院后SARS随访者 ,一线未患SARS健康医护人员及健康体检者血清中IL 1α、IL 1β、TNFα和IL 6含量。结果 :IL 1α和IL 1β含量在早期、恢复期与其他组比较均显著升高 (P <0 0 5 )。SARS早期组TNFα均值显著高于其他组(P <0 0 0 5 ) ,SARS恢复期组均值显著高于SARS随访组、急诊等一线未患SARS组和健康对照组 (P <0 0 1)。SARS早期组IL 6均值显著高于其他各组 (P <0 0 0 5 ) ,SARS随访组与急诊等一线未患SARS组和健康对照组间均值比较 ,均有显著差异 (P <0 0 1)。结论 :SARS在发病过程中其病理损伤与细胞因子IL 1、TNFα和IL 6有关。
Objective: To dynamically monitor the levels of IL-1α, IL-1β, TNFα and IL-6 in patients with SARS and to explore its significance. Methods: The levels of IL-1α, IL-1β, TNFα and IL-6 in sera of patients with SARS in early stage, convalescent stage and SARS follow-up after hospital discharge were analyzed quantitatively by enzyme-linked immunosorbent assay. Results: The levels of IL-1α and IL-1β were significantly increased in early and convalescent periods compared with other groups (P <0.05). The average value of TNFα in the early stage of SARS was significantly higher than that of the other groups (P <0 05). The mean of SARS convalescence stage was significantly higher than that of the SARS follow-up group, and the first line did not have the SARS group and the healthy control group (P <0.01). The mean IL 6 in the early stage of SARS was significantly higher than that in other groups (P <0 0 05). There was a significant difference (P <0.01) between the first and second place in the SARS follow-up group and the emergency department ). Conclusion: The pathological damage of SARS during the pathogenesis is related to the cytokines IL 1, TNFα and IL 6.