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①目的探讨肺癌细胞核形态参数及ＤＮＡ含量与肿瘤生物学行为的关系。②方法应用图象分析技术对８２例原发性肺癌标本进行细胞核形态和ＤＮＡ原位定量测定。③结果在肺腺癌，癌细胞ＤＮＡ含量、核面积、核周长及核形态因子与肿瘤大小、有无淋巴结转移及病人预后均有明显关系，且肿瘤长径＞３ｃｍ组、淋巴结癌转移组的ＤＮＡ六倍体（６Ｃ）以上病例数，均显著多于肿瘤长径≤３ｃｍ组及淋巴结癌转移阴性组（χ２＝７．８３，５．２５；Ｐ均＜０．０５）；以上指标均与肺鳞癌无关。④结论细胞核形态和ＤＮＡ测定对于估测肺腺癌病人的预后有重要意义；且ＤＮＡ－６Ｃ在划分肺腺癌良恶性方面是一个重要的临界点
Objective To investigate the relationship between nuclear morphological parameters, DNA content and tumor biological behavior in lung cancer. 2 Methods Image analysis technique was applied to the quantification of nuclear morphology and DNA in situ in 82 cases of primary lung cancer. 3 results in lung adenocarcinoma, cancer cell DNA content, nuclear area, nuclear perimeter and nuclear morphogenetic factors and tumor size, with or without lymph node metastasis and patient prognosis were significantly related, and tumor long diameter> 3cm group, lymph node metastasis group The number of DNA hexaploids (6C) or more was significantly higher than the tumor length≤3cm group and lymph node metastasis negative group (χ2=7.83, 5.25; P all < 0.05); Not related to lung squamous cell carcinoma. 4 Conclusion Nucleus morphology and DNA determination are important for estimating the prognosis of patients with lung adenocarcinoma; DNA-6C is an important critical point in dividing benign and malignant lung adenocarcinoma.