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本实验采用标准微电极技术对川芎嗪加强豚鼠乳头状肌慢内向电流作用进行了研究。结果表明：①３０ｍｍｏｌ／Ｌ的川芎嗪在正常及儿茶酚胺耗竭的乳头状肌标本上诱发产生慢反应动作电位和收缩活动，在灌流液中加入维拉帕米，可使慢反应动作电位和收缩活动消失。②预先在灌流液中加入心得安，川芎嗪不能诱发产生慢反应动作电位。③增加灌流中Ｃａ２＋浓度，可使川芎嗪诱发产生的慢反应动作电位和收缩活动呈剂量依赖式增加。结果提示：川芎嗪可以加强心肌细胞的慢内向电流［Ｉｓｉ］，这一作用可能是通过β－肾上腺素能受体介导的。
In this study, standard microelectrode technique was used to study the effect of tetramethylpyrazine on the slow inward current of guinea pig papillary muscles. The results showed that 13芎0mmol/L tetramethylpyrazine induced slow response action potentials and contractile activity on normal and catecholamine-depleted papillary muscle specimens, and verapamil was added to the perfusate to allow slow response action potentials and contractions. The activity disappeared. 2 Propranolol was added to the perfusate beforehand. Ligustrazine could not induce slow response action potentials. (3) The increase of Ca2+ concentration in perfusion can increase the dose-dependent increase of the slow response action potential and contraction activity induced by Ligustrazine. The results suggest that tetramethylpyrazine can enhance the slow inward current [Isi] of cardiomyocytes, which may be mediated by β-adrenergic receptors.