目的 :比较Leptin在胃溃疡及胃癌中表达的差异性。方法 :分别通过胃镜和手术获得胃溃疡及胃癌的样品标本 ,用West ern blot法及免疫组化方法 (DAB显色法 )分别检测人胃溃疡组织及胃癌组织中Leptin蛋白的表达情况。结果 :胃癌组织、癌旁组织、溃疡周边组织中均可测量到Leptin蛋白。免疫组化染色结果显示Leptin在癌组织中和胃溃疡周边黏膜均有表达 ,在胃癌组织中表达较强。结论 :Leptin在胃癌组织中表达高于胃溃疡周边组织 ,且两者表达有明显差异性 ,可能与肿瘤的发展有关 Objective: To compare the difference of Leptin expression in gastric ulcer and gastric cancer. Methods: Gastric ulcer and gastric cancer specimens were obtained by endoscopy and operation respectively. Western blotting and immunohistochemistry (DAB staining) were used to detect the expression of Leptin in gastric ulcer and gastric cancer tissues respectively. Results: Leptin protein was detected in gastric cancer tissues, pericarcinomatous tissues and surrounding tissues of ulcer. Immunohistochemical staining showed that Leptin was expressed in both cancerous tissues and peripheral mucosa of gastric ulcer, and strong in gastric cancer tissues. Conclusion: The expression of Leptin in gastric cancer tissue is higher than that of gastric ulcer, and the expression of Leptin is obviously different, which may be related to the development of the tumor