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目的研究干扰素（ＩＦＮ）用于中国城市慢性乙型肝炎患者治疗的经济学意义。方法根据Ｍａｒｋｏｖ理论、以常规治疗为对照，用寿命表法推算干扰素治疗后３０年内每延长一个人年或增加一个生命质量调整年（Ｑｕａｌｉｔｙａｄｊｕｓｔｅｄｌｉｆｅｙｅａｒ，ＱＡＬＹ）的医疗费用。用敏感度分析检验结论的稳定性。结果ＩＦＮ治疗每延长一个人年和每增加一个ＱＡＬＹ的费用不超过２３５９元和１７７５元；而在有些城市这种治疗可以达到节约医疗费用的目的。结论ＩＦＮ治疗慢性乙型肝炎具有良好的成本效果比值，在卫生资源的调配中应考虑该药的合理使用。
Objective To study the economic significance of interferon (IFN) for the treatment of patients with chronic hepatitis B in Chinese cities. Methods According to the Markov theory, routine treatment was used as a control, and life expectancy was used to calculate the medical expenses for every extension of one year or for one QALY within 30 years after IFN treatment. Sensitivity analysis to test the stability of the conclusion. As a result, the cost of extending IFN treatment for one year and QALY for each additional one does not exceed 2,359 yuan and 1,775 yuan. In some cities, this treatment can save medical expenses. Conclusion IFN treatment of chronic hepatitis B has a good cost-effectiveness ratio, the allocation of health resources should consider the rational use of the drug.