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目的：探讨右美托咪定对老年患者全身麻醉拔管质量及苏醒时间的影响。方法全身麻醉下行择期胃癌根治术老年患者60例随机均分为四组：D1、D2和D3组术中分别静脉泵注右美托咪定0.1、0.2和0.4μg · kg‐1· h‐1至术毕前30 min；C组未予右美托咪定泵注作为对照。记录拔管质量评分、自主呼吸恢复时间、呼之睁眼时间、拔管时间和定向力恢复时间。结果 D2、D3组拔管质量评1分（拔管平稳，无呛咳）的人数为8例和9例，多于C组的2例和D1组的3例（ P＜0．01）。与C组、D1组和D2组相比，D3组自主呼吸恢复时间、呼之睁眼时间、拔管时间及定向力恢复时间均延长（P＜0．05或 P＜0．01）。结论全身麻醉术中泵注右美托咪定0.2μg·kg‐1·h‐1可明显提高老年患者拔管质量。“,”Objective To investigate the effects of dexmedetomidine on the quality of extubation and duration of recovery in elderly patients undergoing general anesthesia .Methods Sixty elderly patients scheduled for radical gastric cancer surgery under general anesthesia were equally and randomly divided into 4 groups .Groups of D1 ,D2 and D3 were continuous intravenous infusion of dexmedetomidine 0.1 ,0.2 and 0.4μg · kg‐1 · h‐1 from the beginning to 30 minutes before the end of surgery .Group C did not infuse dexmedetomidine as the control .The extubation quality score and the times of spontaneous breathing recovery ,eye opening at request ,tracheal extubation and orientation regaining were recorded .Results The numbers of patients with extubation quality score of one point (extubated stably without coughing) were 8 cases in group D2 and 9 cases in group D3 ,which were more than 3 cases in group D1 and 2 cases in group C(P<0 .01) .Compared with groups of C ,D1 and D2 ,the times of spontaneous breathing recovery ,eye opening at request ,tracheal extubation and orientation regaining were longer in group D3 ( P<0 .05 or P<0 .01 ) .Conclusion Continuous intravenous infusion of dexmedetomidine 0.2μg · kg‐1 · h‐1 during operation may significantly improve the extubation quality in elderly patients undergoing general anesthesia .