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目的：探讨老年慢性肾脏病（CKD ）患者中性粒细胞明胶酶相关性脂质运载蛋白（NGAL）的变化及意义。方法检测并比较老年CKD患者（A组，62例）和老年健康体检者（C组，30例）晨尿NGAL（uNGAL）和血清肌酐（SCr）、尿素氮（BUN）、血清胱抑素C（CysC）、Hb、RBC等水平。结果 A组uNGAL水平高于C组（P＜0．01）。uNGAL水平与估算肾小球滤过率、Hb和RBC呈负相关（r＝－0．661、－0．514和－0．416，P均＜0．01），与 SCr、BUN、CysC 呈正相关（r＝0．700、0.390、0.598，P均＜0．01）。结论 uNGAL可作为老年CKD早期诊断及肾功能评价指标。“,”Objective To explore the change and significance of neutrophil gelatinase associated lipocalin(NGAL) in elderly patients with chronic kidney disease(CKD) .Methods The morning urine NGAL(uNGAL) ,serum creatinine(SCr) ,blood urea nitrogen(BUN) ,serum cystatin C(CysC) ,red blood cells(RBC) and haemoglobin(Hb) in 62 elderly patients with CKD(group A) and 30 elderly healthy people(group C) were measured and compared .Results The uNGAL was higher in group A than that in group C ( P<0 .01 ) .The uNGAL level was negatively correlated with estimated glomerular filtration rate ,Hb and RBC(r= -0 .661 ,-0.514 and -0.416 ,P<0 .01) and positively correlated with SCr ,BUN and CysC(r=0 .700 ,0.390 and 0.598 ,P<0 .01) .Conclusion uNGAL may be taken as an indicator for early diagnosis and evaluation of renal function in the elderly patients with CKD .