Recent studies on the inhibition of tumor growth by Se-containing polysaccharide were reviewed. Meanwhile, the possible molecular mechanisms of the inhibition of tumor cell growth through antioxidation, induction of tumor cell apoptosis, blockade of cell cycle, and enhancement of immunity by Se-containing poly-saccharide were proposed. In the end, the potential application of Se-containing polysaccharide in the preven-tion and treatment of tumor was elucidated.