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根据生物电子等排原理,设计并合成了一系列新颖的3-胺基取代苯并吡喃酮类化合物.通过1HNMR,13CNMR,MS,IR及元素分析确定其结构.抗肿瘤活性测试结果表明,部分该系列化合物对人结肠癌细胞株HCT116和人肝癌细胞株7721具有较好的抑制活性,其中化合物6c,6f,6i,6m和6o对人肝癌细胞株7721的半数抑制浓度(IC50)值均小于对照品姜黄素(IC50=10.53μmol·L-1),化合物6f对人结肠癌细胞株HCT116和人肝癌细胞株7721的IC50值分别为5.57和4.92μmol·L-1,均小于姜黄素的相应值.
A series of novel 3-amino-substituted benzopyrone compounds were designed and synthesized according to the bioisotopic principle. Their structures were confirmed by 1HNMR, 13CNMR, MS, IR and elemental analysis. The results of antitumor activity test showed that, Some of these compounds have good inhibitory activity on human colon cancer cell line HCT116 and human hepatoma cell line 7721, and the half inhibitory concentration (IC50) of compound 6c, 6f, 6i, 6m and 6o on human hepatoma cell line 7721 (IC50 = 10.53μmol·L-1). The IC50 values of compound 6f on human colon cancer cell line HCT116 and human hepatoma cell line 7721 were 5.57 and 4.92μmol·L-1, respectively, which were less than that of curcumin The corresponding value.