研究胃黏膜细胞恶性演变过程中的分子生物学变化,不仅可以阐明胃癌的发生机制,而且可利用这些基因的变化进行胃癌的早期诊断、早期预防和早期治疗。基于以上认识,我们从胃癌发生的分子基础及防治方面进行了较为深入系统的研究。1胃癌发生的基础1.1胃癌与基因不稳定性基因不稳定 Studying the molecular biological changes in the malignant evolution of gastric mucosal cells can not only clarify the mechanism of gastric cancer, but also make use of the changes of these genes for the early diagnosis, early prevention and early treatment of gastric cancer. Based on the above understanding, we conducted a more in-depth and systematic study on the molecular basis and prevention and treatment of gastric cancer. 1 The basis of gastric cancer 1.1 Gastric cancer and gene instability Gene instability