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目的：观察青蒿乙醇提取物对H22肝癌小鼠的体内抑瘤作用。方法：1.利用紫外-可见分光光度法测定青蒿乙醇提取物中总黄酮与粗多糖的含量2.取H22肝癌细胞接种于小鼠右腋皮下，随机分为模型对照组、环磷酰胺（CTX）20mg/kg组和青蒿乙醇提取物125mg/kg组、500mg/kg组。CTX组腹腔注射给药，其余各组灌胃给药，连续给药10天后，解取肿瘤称取重量，计算抑瘤率。结果：1.青蒿乙醇提取物中总多糖含量为6.45%，总黄酮的含量为16.2%2.与模型对照组比较，青蒿乙醇提取物组500mg/kg可抑制肿瘤生长( P＜0.05)，抑瘤率为48.7%。结论：青蒿乙醇提取物对小鼠H22肝癌有明显的抑制作用，中药青蒿中可能存在其它的抗肿瘤成分。“,”ObjectiveObserve the inhibitory effect of Artemisia Ethanol Extract on tumor growth on murine transplanted hepatocarcinoma 22(H22)in vivo.Methods 1.Use UV - visible spectrophotometry to determinate the content of total flavonoids and total polysaccharides in Artemasia Ethanol Extract. 2.Tumor inhibitory activities were tested in experimental tumor H22 mice.The tumor bearing mice were randomly divided into control groud,CTX group(20mg/kg)and Artemisia Ethanol Extract treatment groups(125mg/(kg.d) group,500mg/(kg.d)group).These mice were given normal saline,or Artemasia Ethanol Extract different doses by gavage respectively once a day for 10 days,while CTX were given by intraperitoneal injection.Tumor growth state was observed and tumor inhibitory rate was calculated.Results 1.The content of total polysaccharides content was 6.45%, the content of total flavonoids was 16.2%. 2.Artemasia Ethanol Extract treated groups with high dose(500 mg/(kg.d)) could inhibit hepatocarcinoma 22(H22)(P<0.05),the inhibitory rate was 48.7%.ConclusionsArtemisia Ethanol Extract can nihibit hepatocarcinoma growth,except Artemisinin,other anti-tumor components may exist in Artemisia annua.