血管支架已被广泛应用于临床治疗心血管疾病,但由此产生的并发症也日益显露出来。支架置入后血管内皮功能异常,引发内皮层剥脱,导致血小板聚集、炎症反应、血管平滑肌细胞增殖迁移、细胞外基质形成等一系列病理反应,造成支架内再狭窄。本文从血管内皮细胞的功能与支架置入后血管内皮化的关系及支架涂层材料对支架置入后血管内皮化的影响作一综述。 Vascular stents have been widely used in the clinical treatment of cardiovascular diseases, but the resulting complications have become increasingly apparent. Stent implantation endothelial dysfunction, causing endothelial stripping, leading to platelet aggregation, inflammation, vascular smooth muscle cell proliferation and migration, extracellular matrix formation and a series of pathological reactions, resulting in stent restenosis. This article reviewed the relationship between the function of vascular endothelial cells and vascular endothelialization after stent implantation and the effect of stent coating material on vascular endothelialization after stent implantation.