尿毒症毒素是一大组体内代谢的产物,在肾功能衰竭患者体液中水平明显升高,并与尿毒症毒素代谢紊乱或临床表现密切相关。部分毒素可与蛋白结合,形成大分子复合物,称为蛋白结合毒素。它们具有多种生物学作用,产生一系列尿毒症并发症,如心血管疾病、免疫功能紊乱、脏器纤维化等。研究发现:血浆分离吸附、高通量血液透析、服用肠道吸附剂等方法可增加蛋白结合毒素的清除。评价尿毒症患者的透析充分性时,也应考虑到蛋白结合毒素。 Uremic toxins are a large group of metabolites in the body that are significantly elevated in body fluid in patients with renal failure and are closely linked to metabolic disorders or clinical manifestations of uremic toxins. Some toxins can bind to proteins to form macromolecular complexes called protein-bound toxins. They have a variety of biological effects, resulting in a series of uremic complications such as cardiovascular disease, immune dysfunction, organ fibrosis and so on. The study found that: plasma separation and adsorption, high-throughput hemodialysis, taking intestinal adsorbent and other methods can increase protein-bound toxin removal. When evaluating dialysis adequacy in patients with uremia, protein-bound toxins should also be considered.