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【摘要】目的:观察两种药物对冠心病的疗效。方法:患者均来自2019年1月至12月我院心内科收入的冠心病患者78例,抽样分为对照组(拜阿司匹林),观察组(氯吡格雷),比较血小板聚集率和用药效果。结果:观察组和对照组的结果比较有差异(P<0.05),前者聚集率更低。观察组药物使用后病情得到缓解的患者更多(P<0.05),有差异性。结论:目前冠心病的不同种类抗血小板治疗药物有很多,联合用药的效果更加明显,可以推广使用范围。但是,药物的起效时间与副反应还需深入研究。
【关键词】冠心病;氯吡格雷;拜阿司匹林;凝血有效率;治疗效果;凝血指标
[中图分类号]R541.4 [文献标识码]A [文章编号]2096-5249(2021)09-0077-02
The clinical effect of different antiplatelet drugs in the treatment of coronary heart disease
ZHU Zhen-yu (Department of pharmacy, Jiangmen Central Hospital, Jiangmen Guangdong 529000, China)
[Abstract] Objective: To observe the effect of two drugs on coronary heart disease. Methods: 78 patients with coronary heart disease from January to December 2019 in the department of Cardiology of our hospital were sampled and divided into control group (aspirin) and observation group (Clopidogrel), and the platelet aggregation rate and the effect of medication were compared. Results: The results of the observation group and the control group were different(P<0.05), the former was lower aggregation rate. There were more patients in the observation group whose disease was relieved after drug use (P<0.05), showing a difference. Conclusion: At present, there are many different kinds of antiplatelet drugs for CORONARY heart disease, and the effect of combination is more obvious, which can be popularized. However, the onset time and side effects of the drug need to be further studied.
[Key words] Coronary heart disease (CHD); Clopidogrel; Aspirin; Coagulation efficiency; Therapeutic effect; Blood coagulation indexes
冠心病屬于心血管病范畴[1],具有多发性、复杂性、难治性,受到饮食、生活、工作、环境、遗传等多种因素影响,该病症每年的发病率都在增加,且发病患者的年龄逐渐趋于年轻化。随着科技的发展,药物洗脱支架应用越来越广泛[2-3],相较于金属支架而言,该材质能有效降低动脉再狭窄现象。手术治疗后[4],一些患者的支架内会出现血栓,对于后造成严重影响。因此,选择有效的抗血小板药物非常关键。文章对2018年5月至11月选取的78例冠心病患者,提供不同种类抗血小板药物,比较疗效,报道如下。
1 资料与方法
1.1基本资料 纳入冠心病患者78例,为2019年上半年在我院诊治的患者,通过抽样方式平均分为对照组、观察组。观察组,男22例、女14例;年龄39~77岁,平均年龄(53.8±4.7)岁。对照组,男24例、女12例;年龄41~75岁,平均年龄(55.2±4.4)岁。通过心功能指标诊断,进入实验研究的患者已经全部确诊,并获得伦理协会审批,每名患者都知晓实验内容。研究不同组间患者的个人信息(P>0.05),无差异性。
1.2治疗方法 对照组中的患者,在实验进行期间口服拜阿司匹林(厂家:拜耳医药保健公司;国药准字J20130078)1片/d。观察组加入口服氯吡格雷(厂家:赛诺菲药物;国药准字J20130083;75 mg)1片/d。全部实验人员均需要连续治疗28 d。
1.3观察指标与疗效判定 对两组患者的治疗前后的各项凝血指标进行比较,包括血小板聚集率与治疗效果。
1.4统计分析 统计分析的应用软件为SPSS21.0,计量数据应用x±s表示,计数数据应用χ2检验,P<0.05,有差异性。
2 结果
2.1比较两组患者治疗前后的各项凝血指标 观察组血小板聚集率低于对照组(P<0.05),统计学有差异性。详见表1。
2.2比较两组患者治疗有效率 观察组中,2例无效,有效率为94.4%;对照组中,9例无效,有效率为75%,观察组患者所获得的药物使用效果高于对照组(P<0.05),有差异性。
【关键词】冠心病;氯吡格雷;拜阿司匹林;凝血有效率;治疗效果;凝血指标
[中图分类号]R541.4 [文献标识码]A [文章编号]2096-5249(2021)09-0077-02
The clinical effect of different antiplatelet drugs in the treatment of coronary heart disease
ZHU Zhen-yu (Department of pharmacy, Jiangmen Central Hospital, Jiangmen Guangdong 529000, China)
[Abstract] Objective: To observe the effect of two drugs on coronary heart disease. Methods: 78 patients with coronary heart disease from January to December 2019 in the department of Cardiology of our hospital were sampled and divided into control group (aspirin) and observation group (Clopidogrel), and the platelet aggregation rate and the effect of medication were compared. Results: The results of the observation group and the control group were different(P<0.05), the former was lower aggregation rate. There were more patients in the observation group whose disease was relieved after drug use (P<0.05), showing a difference. Conclusion: At present, there are many different kinds of antiplatelet drugs for CORONARY heart disease, and the effect of combination is more obvious, which can be popularized. However, the onset time and side effects of the drug need to be further studied.
[Key words] Coronary heart disease (CHD); Clopidogrel; Aspirin; Coagulation efficiency; Therapeutic effect; Blood coagulation indexes
冠心病屬于心血管病范畴[1],具有多发性、复杂性、难治性,受到饮食、生活、工作、环境、遗传等多种因素影响,该病症每年的发病率都在增加,且发病患者的年龄逐渐趋于年轻化。随着科技的发展,药物洗脱支架应用越来越广泛[2-3],相较于金属支架而言,该材质能有效降低动脉再狭窄现象。手术治疗后[4],一些患者的支架内会出现血栓,对于后造成严重影响。因此,选择有效的抗血小板药物非常关键。文章对2018年5月至11月选取的78例冠心病患者,提供不同种类抗血小板药物,比较疗效,报道如下。
1 资料与方法
1.1基本资料 纳入冠心病患者78例,为2019年上半年在我院诊治的患者,通过抽样方式平均分为对照组、观察组。观察组,男22例、女14例;年龄39~77岁,平均年龄(53.8±4.7)岁。对照组,男24例、女12例;年龄41~75岁,平均年龄(55.2±4.4)岁。通过心功能指标诊断,进入实验研究的患者已经全部确诊,并获得伦理协会审批,每名患者都知晓实验内容。研究不同组间患者的个人信息(P>0.05),无差异性。
1.2治疗方法 对照组中的患者,在实验进行期间口服拜阿司匹林(厂家:拜耳医药保健公司;国药准字J20130078)1片/d。观察组加入口服氯吡格雷(厂家:赛诺菲药物;国药准字J20130083;75 mg)1片/d。全部实验人员均需要连续治疗28 d。
1.3观察指标与疗效判定 对两组患者的治疗前后的各项凝血指标进行比较,包括血小板聚集率与治疗效果。
1.4统计分析 统计分析的应用软件为SPSS21.0,计量数据应用x±s表示,计数数据应用χ2检验,P<0.05,有差异性。
2 结果
2.1比较两组患者治疗前后的各项凝血指标 观察组血小板聚集率低于对照组(P<0.05),统计学有差异性。详见表1。
2.2比较两组患者治疗有效率 观察组中,2例无效,有效率为94.4%;对照组中,9例无效,有效率为75%,观察组患者所获得的药物使用效果高于对照组(P<0.05),有差异性。