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目的调查在孕妇应用硫酸镁和早产儿发生大脑性瘫痪及死亡等的关联,评价产前应用硫酸镁对早产儿的安全性及可行性。方法检索有关产前使用硫酸镁与早产儿发生大脑性瘫痪及死亡的病例对照研究文献进行Meta分析。结果符合研究纳入标准的文献9篇,共3800个研究例数,其中有5项研究是对孕妇应用硫酸镁有无导致早产儿发生死亡进行病例对照分析,4项研究对孕妇应用硫酸镁有无导致早产儿发生大脑性瘫痪进行病例对照分析。通过Meta分析,发现产前使用硫酸镁可以降低早产儿发生死亡的概率(OR:0.75;95%CI:0.59-0.95),而与早产儿发生大脑性瘫痪则无相关(OR:0.79;95%CI:0.60-1.04)。结论研究提示产前应用硫酸镁对早产儿发生死亡的几率有降低作用。
Objective To investigate the association between cerebral palsy and death in pregnant women applying magnesium sulfate and premature children and to evaluate the safety and feasibility of prenatal application of magnesium sulfate in premature infants. Methods Meta-analysis was performed on case-control studies of pre-natal use of magnesium sulfate and preterm infants with cerebral palsy and death. The results of the study met the inclusion criteria of 9 articles, a total of 3800 cases of research, of which five studies are pregnant women with or without magnesium sulfate cause death in premature children case-control analysis of four studies of pregnant women with or without magnesium sulfate Lead to cerebral palsy in preterm children for case-control analysis. Meta-analysis found that prenatal use of magnesium sulfate reduced the risk of premature death (OR: 0.75; 95% CI: 0.59-0.95), but not to cerebral palsy in preterm infants (OR: 0.79; 95% CI: 0.60-1.04). Conclusion The study suggests that prenatal application of magnesium sulfate reduces the risk of premature death.