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本文报告坦桑尼亚半免疫力者中的2例抗氯喹恶性疟。例1,32岁,男性,在达累斯萨拉姆居住13年以上,1981年11月患恶性疟。在当地曾先后注射氯喹200mg(基质或盐类)计20次、口服氯喹数片与注射奎宁1次。1982年3月2日就诊,3月3日血检查见恶性疟滋养体,尿检氯喹阴性,随即给于标准量氯喹治疗,第1、2天各服10mg/kg(基质)、第3天5mg/kg。服药后尿检证实氯喹已被吸收。第5天疟原虫消失,第7天原虫再现,直到第21天原虫继续增多且出现疟疾症状。第22天给服每片含磺胺甲基异恶唑400mg与甲氧苯氨嘧啶80mg的合剂,每次2片,每日2次,连服7天。由于病人出现临床症状,故未能按WHO的现场试验要求观察至28天。但该病人可能为一级抗性(RI)。
This article reports 2 out of 2 anti-chloroquine-resistant malaria cases in Tanzania’s semi-immunity. Example 1, 32 years old, male, living in Dar es Salaam for more than 13 years and suffering from falciparum malaria in November 1981. In the local injection of chloroquine has 200mg (matrix or salt) meter 20 times, oral administration of chloroquine tablets and injection of quinine 1. March 2, 1982 for treatment, March 3 blood examination to see the P. falciparum trophozoites, urine tests of chloroquine negative, then given to the standard amount of chloroquine treatment, the first and second days of each serving 10mg / kg (matrix), the first 3 days 5mg / kg. After taking urine test confirmed chloroquine has been absorbed. Plasmodium disappeared on day 5 and reappeared on the 7th day. Protozoa continued to grow on day 21 with symptoms of malaria. On the 22nd day for each serving containing sulfamethoxazole 400mg and methoxypyridazine 80mg mixture, each 2 tablets, 2 times a day, and even served 7 days. Due to the clinical symptoms of patients, it failed to observe the field test of WHO to 28 days. However, this patient may be primary resistance (RI).