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安妥明是目前使用较为普遍的血脂药,由于其在常温为油状液体,比重较大(15℃时为1.140),选择其应用剂型时遇到一定的局限性,据文献报导,可将安妥明与聚乙二醇6000混合熔融,粉碎,压片或盛装在胶囊中应用(含主药5~10%);国内有掺加一定量花生油(125mg安妥明、59mg花生油),用模压成胶丸的;也有掺加等量液体石蜡用滴丸法进行生产的。1973年以来,我们进行了直接采用安妥明原油以滴丸
Clofibrate is currently used more commonly lipid-lowering drugs, because of its oily liquid at room temperature, a larger proportion (15 ° C when 1.140), select its application dosage forms have encountered some limitations, according to the literature, Mixed with polyethylene glycol 6000 and melted, crushed, tabletted or contained in a capsule (containing 5 to 10% of the main drug); a certain amount of peanut oil (125mg of collins, 59mg of peanut oil) ; There is also mixed with the same amount of liquid paraffin method using the pill production. Since 1973, we have carried out the direct use of crude oil to drop pills