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我們熟知飽和碳氫化合物不易起化学反应,就是含有活性官能团或双鍵等基团的碳氫化合物,如果要在与官能团或其他活性基团不靠近的碳氫部簇上使起置换反应,也是甚为困难,尤其是甾体化合物中两个夹在两环中的竪鍵角甲基(C_(18)及C_(19)),一向认为格外难起置换反应。所以凡需改变这种甲基的合成素认为絕非易事。例如从动物提出的具有高度生理作用的醛固酮(aldosterone)(1),其C_(18)上带有醛基,而自然界没有在C_(18)上具有官能团易于进行改造的化合物,要在18-甲基上进行置换反应改变为醛基,当初认为絕非易
We are familiar with saturated hydrocarbons is not easy to play a chemical reaction, that is, containing active functional groups or double bonds and other hydrocarbon groups, if not in the functional groups or other reactive groups near the hydrocarbon cluster to make the displacement reaction, but also Very difficult, especially steroid compounds in the two rings in the two bond ring methyl (C_ (18) and C_ (19)), has always been considered particularly difficult to replace the reaction. Therefore, any need to change the methyl synthetic hormone that is by no means easy. For example, the highly physiologically active aldosterone (1) proposed by the animal possesses aldehyde groups on C_ (18) and no compounds in nature that are easily modified with functional groups on C_ (18) Replacement of the reaction on the methyl aldehyde, did not think it was easy