论文部分内容阅读
人类精子在体外不能激发同种淋巴细胞反应, 但抗精子抗体则可作为精子转化成干扰素(IFN-γ)及使淋巴细胞活化的诱导剂。如果该作用机理在体内也相同,那么,当抗精子抗体接触妇女体内精液中对其敏感的精子时,则可产生相当水平的IFN-γ,并可从妇女循环血中测出。 68对不育夫妇中的女性作为研究对象,在研究过程中该68对夫妇均未使用抗精子抗体的免疫抑制剂,并且未使用避孕套,支原体、衣原体、淋病奈瑟氏菌培养阴性。研究前可因上述一种或一种以上
Human sperm can not stimulate allogeneic lymphocyte responses in vitro, but anti-sperm antibodies can act as an inducer of sperm into interferon (IFN-γ) and lymphocyte activation. If this mechanism of action is the same in vivo, then, when antisperm antibodies are exposed to sperm that is sensitive to them in women’s semen, a comparable level of IFN- [gamma] is produced and can be measured in women’s circulating blood. 68 Women among infertile couples were included in the study. None of the 68 couples used immunosuppressive anti-sperm antibodies during the study and did not use condoms, Mycoplasma, Chlamydia, and Neisseria gonorrhoeae for culture negative. Before the study may be due to one or more of the above