近年来对牙周病的病因和病原的认识不断加深,同时,对牙髓病中的微生物的认识也得到重视。连续厌氧培养技术增加了厌氧菌的检出率,也为我们提供了根管内和根尖部菌群的详细知识。最近的研究显示了晚期牙周病和牙髓病中菌群的高度相似,提示交叉感染的存在。本文对最可能参与这种感染的细菌进行综述,以说明这种相似。革兰氏(G)阴性菌是具坏死牙髓的完整根管和牙周袋中的优势菌 In recent years, the understanding of the etiology and pathogens of periodontal diseases has been deepening. At the same time, the understanding of microorganisms in endodontics has also been taken seriously. Continuous anaerobic culture increases the detection rate of anaerobic bacteria and provides us with detailed knowledge of the root canal and root apical flora. Recent studies have shown similarities between late periodontal and endodontic bacterial populations, suggesting the existence of cross-infection. This article reviews the bacteria most likely to be involved in this infection to illustrate this similarity. Gram (G) -negative bacteria are the dominant bacteria in the complete root canal and periodontal pocket with necrotic pulp