五年前,Zipper等在宫内避孕器上加一小段铜丝,增强了避孕效果。铜在动物子宫内产生各种作用,小量铜对哺乳动物胚胎植入前有毒,子宫炎症的反应能引起子宫内膜间质及上皮白细胞集聚。带铜丝T形避孕器导致子宫生理学多方面的变化,如微量元素水平、子宫组织的细胞化学、大分子和酶 Five years ago, Zipper et al. Added a small piece of copper wire to an intrauterine device to enhance contraception. Copper produces various effects in the animal’s uterus. A small amount of copper is poisonous to mammalian embryos before implantation, and the reaction of uterine inflammation can cause the aggregation of endometrial stroma and epithelial leucocytes. Copper wire T-shape contraceptives lead to various aspects of uterine physiology such as trace element levels, cytochemistry of uterine tissue, macromolecules and enzymes